DIPHENCYPRONE (DCP)TREATMENT FOR ALOPECIA AREATA
The term alopecia means hair loss. In the form of alopecia known as
alopecia areata, round bald patches appear suddenly, most often affecting the scalp.
However, the eyebrows, eyelashes, beard and other areas can be affected.
Alopecia areata is often discovered by a hairdresser, as there are
usually no symptoms. The hair stops growing and then falls out from the roots.
Alopecia areata is considered to be one of the autoimmune disorders whereby lymphocytes
around the hair follicles release chemical messengers that reject the hair for
unknown reasons. The treatment of alopecia areata include topical steroids,
steroid injections as well as chemical treatments such as diphencyprone or
Nurse applying DCP for patient.
How does DCP work?
DCP works by inducing contact dermatitis. The body’s immune system is
stimulated causing inflammation on the surface of the skin. By diverting the
white blood cells away from the hair bulb, the hairs can re-grow. DCP does not
work in every patient, but reports suggest that up to 50% of people who use it
will obtain significant re-growth of their hair.
What would you expect if your doctor put you on DCP?
DCP treatment usually involves making you allergic to this chemical by
“sensitizing” you to the chemical DCP. This chemical is painted on a small
patch on your scalp and left on for 24 hours.
After 24-hours, you should remove the patch by wiping the chemical with
a tissue before washing the area in the shower. An itchy area or even blister will
develop in 3 to 5 days where the DCP is applied. This itchy area will fade in
(2 weeks after sensitization)
You need to see the doctor 2 weeks after the “sensitization” period.
Your doctor will examine you and decide if DCP will work for you. If you have a
reaction to DCP (you developed an itch or blister 3-5 days after
“sensitization”), this means that you have been successfully sensitized to DCP.
(usually applied weekly)
DCP is usually applied once a week. DCP comes in many concentrations
(0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1% etc) and your doctor will choose
the best concentration to start treating you with. In the treatment room, your
nurse will apply DCP to your scalp. After treatment, you should keep the
treated areas covered. After 24 hours, you will be required to wash off all the
remaining chemical from your scalp.
Once you have been sensitized to the DCP, you will get a rash wherever
it touches you. So you must be careful when you wash away the remaining
chemical to make sure that it does not come into contact with other parts of
What can you expect after each treatment?
One to two days after your treatment, you may experience itching,
buming, blistering on the scalp and may even look like a mild sunburn.
Different people react differently and some people will only have a mild
redness and slight itch, whilst others may get a very severe itch and even few
blisters. A satisfactory reaction is for the DCP to cause mild redness,
tolerable itchiness and/or mild scaliness lasting 24-48 hours.
The redness and itch is then allowed to subside, and the DCP is
applied each week. DCP will be continued until the bald area has completely regrown.
This will usually take several months. If you get a strong reaction such as
blistering, intense or intolerable itch, and/or extensive scaliness, please
inform your nurse and no treatment will be done until your reaction settles.
Some patients will develop painful swellings (lymph nodes) at the back of the
neck. It is generally benign. Please see your doctor.
Your doctor will review you at regular intervals after starting
treatment. He will adjust the concentration of DCP applied according to your
response to the previous concentration. DCP treatment should be continued for
at least 6-12 months before it is considered unsuccessful.
When the treatment is deemed successful and you have achieved complete
re-growth, your doctor will either reduce the frequency and put on a
maintenance regime or stop the treatment completely.
Treatment with DCP is usually safe and any side effects is usually due
to hypersenstivity to the chemical. You can develop redness, itch, blisters and
white or brown patches. If you are extremely sensitive to the chemical you
might even develop rashes on other parts of the body, not exposed to the
chemical. If this happens, and it is extensive and severe, you are required to
stop the treatment and to consult your doctor immediately.
At all times when on treatment, YOU
MUST NOT BE PREGNANT OR BREASTFEEDING. The effects of DCP in pregnancy is unknown. Should you be pregnant while on treatment, you should stop your DCP treatment immediately and inform your doctor.
DEDICATED TO EXCELLENCE IN DERMATOLOGY
By National Skin Centre (Singapore)
Copyright (C) 1995 - National Skin Centre (Singapore)