National Skin Centre offers a
comprehensive range of laboratory tests for the diagnosis of a wide variety of
dermatological diseases. The professional staff is experienced in the
histological diagnosis of dermatological diseases and in the interpretation of
pathological findings. The specialised laboratory services include:
cultures and identification of dermatophytes, moulds and yeasts for nail, hair
and skin specimens.
Examination of hair
shaft abnormalities and anagen: telogen counts.
examination of skin specimens with a spectrum of tests for histochemistry and
Examination of formalin-fixed
parafiin embedded skin specimens for immunophenotyping (for example
lymphoproliferative disorders and characterisation of tumor differentiation).
Direct and indirect
immunofluorescence tests for the diagnosis of immunobullous diseases,
connective tissue diseases and vasculitis.
•Enzyme-linked Immunosorbent Assay (ELISA)
Assays for detection
of antibodies against desmoglein 1, desmoglein 3, BP (Bullous pemphigoid) 180
and BP 230 and Type VII collagen for the diagnosis of immunobullous diseases.
We have a
interlaboratory network for PCR detection of mycobacterium tuberculosis, herpes
simplex virus in skin or other tissue specimens, detection of clonal T-cell
receptor gene rearrangement, IgH heavy chain gene rearrangements in
lymphoproliferative disorders and in-situ hybridization of EBV (EBER).
Dermatopathology and Laboratory Services
Dr Joyce Lee
Mr Lee Sau Chuen
Our office is
located on Level 4, Laboratory
Skin Centre and is the
reception centre for specimens
sent from other
hospitals, clinics and
Tel: (65) 6350 8581 (general
(65) 6350 8592 (histology)
Fax: (65) 6350 8588
Mondays to Fridays:
8.00am to 12.00pm
and public holidays closed.
A transport service
for collection of specimens for private dermatologists in Singapore is provided
by National Skin Centre. Please call 6350 8436 for appointment. Collection of
specimens is during office hours between 9.00am and 3.00pm. For centres outside
Singapore, specimens should be sent by courier service to the above address. The
courier fee will be borne by the sender.
Specimens should be
accompanied by a request form or a letter, stating the laboratory test that is requested
for. A short clinical history will help in the clinicopathological correlation
and in the interpretation of test results. The referring clinician and the
contact number of clinician or person to contact should also be provided.
a. Specimens for
histology should be sent in 10% formalin within 7 days of biopsy.
b. Specimens for
direct immunofluorescence studies should be sent in Michel’s holding medium
within 7 days of biopsy. The holding medium is provided by NSC laboratory upon
request and can be dispatched to the referring clinic or hospital in advance. For
centres outside Singapore, a charge for postage will be levied.
c. Blood specimens
(5 mls) for indirect immunofluorescence studies can be sent in plain tubes.
a. A faxed histology
report is available, usually within 3 working days of specimen collection.
Allowance should be made for cases requiring further sections, special stains
b. Reports for
immunofluorescence are available within a week of specimen collection.
All faxed reports will be followed by